3’-O-Levulinyl-2’-deoxyadenosine

Names

[ CAS No. ]:
440327-45-7

[ Name ]:
3’-O-Levulinyl-2’-deoxyadenosine

[Synonym ]:
Adenosine, 2'-deoxy-3'-O-(1,4-dioxopentyl)-
2'-Deoxy-3'-O-(4-oxopentanoyl)adenosine

Biological Activity

[Description]:

3’-O-Levulinyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
640.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H19N5O5

[ Molecular Weight ]:
349.34

[ Flash Point ]:
341.3±34.3 °C

[ Exact Mass ]:
349.138611

[ LogP ]:
-0.51

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.716

Related Compounds