AMXT-1501

AMXT-1501 (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination of with DFMO; completely blocked radiolabeled spermidine uptake in multiple NB cell lines, whereas the combination of AMXT 1501 and DFMO was synergistic in reducing colony formation in BE(2)-C and KELLY cells; The combination treatment resulted in hypophosphorylation of retinoblastoma protein (Rb), suggesting growth inhibition via G1 cell cycle arrest in NB cells; inhibits polyamine synthesis and uptake, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO. Solid Tumors Phase 1 Clinical

References 1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099. 2. Samal K, et al. Int J Cancer. 2013 Sep 15;133(6):1323-33. 3. Hayes CS, et al. Cancer Immunol Res. 2014 Mar;2(3):274-85. 4. Murray-Stewart TR, et al. Biochem J. 2016 Oct 1;473(19):2937-53. View Related Products by Target Other Targets Solid Tumors