VU714
Names
[ CAS No. ]:
441289-66-3
[ Name ]:
VU714
Biological Activity
[Description]:
A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).
[References]
References 1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. 2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. View Related Products by Target Potassium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C22H23ClN2O
[ Molecular Weight ]:
366.889