Norwogonin

Names

[ Name ]:
Norwogonin

[Synonym ]:
Norwogonin
5,7,8-Trihydroxyflavone
5,7,8-trihydroxy-2-phenyl-chromen-4-one
FLAVONE,5,7,8-TRIHYDROXY
2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one
5,7,8-trihydroxy-2-phenylchromen-4-one
5,7,8-Trihydroxy-2-phenyl-chromen-4-on

Biological Activity

[Description]:

Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1]

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 31.83 μg/ml (EV71)[1]

[In Vitro]

Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection[1]. Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression[1]. Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h[1].

[References]

[1]. Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71. Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.

Chemical & Physical Properties

[ Density]:
1.548g/cm3

[ Boiling Point ]:
528.4ºC at 760 mmHg

[ Melting Point ]:
258 ºC (ethanol )

[ Molecular Formula ]:
C₁₅H₁₀O₅

[ Molecular Weight ]:
270.23700

[ Flash Point ]:
206ºC

[ Exact Mass ]:
270.05300

[ PSA ]:
90.90000

[ LogP ]:
2.57680

[ Index of Refraction ]:
1.732

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Very slightly soluble (0.26 g/L) (25 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9276100

CHEMICAL NAME :: Flavone, 5,7,8-trihydroxy-

CAS REGISTRY NUMBER :: 4443-09-8

BEILSTEIN REFERENCE NO. :: 0272168

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H10-O5

MOLECULAR WEIGHT :: 270.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR& GQ IQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 nmol/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,474,1983

Safety Information

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%