ALPHA-THYMIDINE

Names

[ CAS No. ]:
4449-43-8

[ Name ]:
ALPHA-THYMIDINE

[Synonym ]:
L-Dt
MFCD00069766
L-2'-deoxythymidine
Epavudine
2'-DEOXY-L-THYMIDINE
NV 02B
L-Deoxythymidine

Chemical & Physical Properties

[ Density]:
1.452g/cm3

[ Molecular Formula ]:
C₁₀H₁₄N₂O₅

[ Molecular Weight ]:
242.22900

[ Exact Mass ]:
242.09000

[ PSA ]:
104.55000

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

Bioorg. Med. Chem. 19(24) , 7603-1, (2011)

We report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives. In addi...

Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors.

J. Chem. Inf. Model. 49 , 1070-1078, (2009)

Thymidine monophosphate kinase (TMPK) has emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. In this study the receptor-independent (RI) 4D-QSAR formalism ...

Chemical synthesis of hydroxymethylphosphonate alpha-DNA.

Nucleic Acids Symp. Ser. 44 , 31-32, (2000)

In this paper, we report the synthesis of hydroxymethylphosphonate alpha-DNAs and related compounds by use of the H-phosphonate method. These modified alpha-DNAs were designed to improve the inherent ...