BBT

Names

[ CAS No. ]:
445000-45-3

[ Name ]:
BBT

Biological Activity

[Description]:

BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ)-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Metabolic Disease

[Target]

L-type voltage-dependent Ca2+ channel/CaMK2[1]


[References]

[1]. Yao XG, et al. BBT improves glucose homeostasis by ameliorating 尾-cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224(3):327-41.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12BrNO2S

[ Molecular Weight ]:
386.26

Related Compounds