NSD3-IN-3

Names

[ CAS No. ]:
445416-12-6

[ Name ]:
NSD3-IN-3

Biological Activity

[Description]:

NSD3-IN-3 is a potent NSD3 inhibtor with an IC50 value of 1.86 μM. NSD3-IN-3 has anticancer activity and significantly inhibits the growth and proliferation of non-small cell lung cancer cell line H460[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

NSD3:1.86 μM (IC50)


[In Vitro]

NSD3-IN-3 (化合物 B2) (0-10 μM; 48 h) 在 10 μM 下完全抑制 H460 和 H1299 细胞中 H3K36me3 修饰[1]。 NSD3-IN-3 (0-20 μM; 48 h) 抑制 H460 细胞的生长[1]。 Cell Viability Assay[1] Cell Line: Non-small cell lung cancer cell line H460 Concentration: 0, 2.5, 5, 10, and 20 μM Incubation Time: 48 hours Result: Inhibited cell growth dose-dependently.

[References]

[1]. Kong Ren, et al. Application of compound B2 as histone methyltransferase NSD3 inhibitor: China, CN109223795[P].2019-01-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H17N5O2S

[ Molecular Weight ]:
331.39

Related Compounds