phosphoric acid,pyridine-3,4-diamine

Names

[ CAS No. ]:
446254-47-3

[ Name ]:
phosphoric acid,pyridine-3,4-diamine

[Synonym ]:
Amifampridine phosphate
3,4-Diaminopyridine phosphate
UNII-8HF8FIN815
Firdapse
Zenas

Biological Activity

[Description]:

Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vivo]

Amifampridine phosphate treatment (Intravenous injection; 2.5 mg/kg; once) shows 1 hour plasma half-life[2]. Amifampridine phosphate treatment (Oral administration; 10 mg/kg; once) shows plasma concentrations spike[2]. Animal Model: Mice[2] Dosage: 2.5 mg/kg Administration: Intravenous injection; 2.5 mg/kg; once Result: Had a plasma half-life of about 1 hour. Animal Model: Mice[2] Dosage: 10 mg/kg Administration: Oral administration; 10 mg/kg; once Result: Exhibited a rapid spike in plasma concentrations.

[References]

[1]. Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10(12):1098-107.

[2]. T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90.

Chemical & Physical Properties

[ Molecular Formula ]:
C5H10N3O4P

[ Molecular Weight ]:
207.12400

[ Exact Mass ]:
207.04100

[ PSA ]:
153.23000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds