4-Fluoro-2-methoxyphenol

Names

[ CAS No. ]:
450-93-1

[ Name ]:
4-Fluoro-2-methoxyphenol

[Synonym ]:
MFCD00070797
4-Fluoro-2-methyoxyphenol
Phenol,4-fluoro-2-methoxy
4-fluoroguaiacol
Phenol, 4-fluoro-2-methoxy-
2-Methoxy-4-fluorophenol
3-methoxy-4-hydroxyfluorobenzene
4-Fluoro-2-methoxyphenol
4-fluoro-2-methoxy-phenol
5-Fluoro-2-hydroxyanisole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
201.9±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₇FO₂

[ Molecular Weight ]:
142.128

[ Flash Point ]:
101.4±18.3 °C

[ Exact Mass ]:
142.043015

[ PSA ]:
29.46000

[ LogP ]:
1.52

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.512

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2735

[ WGK Germany ]:
3

[ HS Code ]:
2909500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Oxidation of substituted 4-fluorobenzaldehydes: application to the no-carrier-added syntheses of 4-[18F]fluoroguaiacol and 4-[18F]fluorocatechol.

Int. J. Rad. Appl. Instrum. A. 42(7) , 673-81, (1991)

The synthesis of 4-[18F]fluoroguaiacol (4-[18F]fluoro-2-methoxyphenol) has been achieved in no-carrier-added form starting from 2-methoxy-4-nitrobenzaldehyde, using nucleophilic aromatic substitution ...

4-fluoro-2-methoxyphenol, an apocynin analog with enhanced inhibitory effect on leukocyte oxidant production and phagocytosis.

Eur. J. Pharmacol. 660(2-3) , 445-53, (2011)

Apocynin, a methoxy-substituted catechol (4-hydroxy-3-methoxyacetophenone), originally extracted from the roots of Picrorhiza kurroa, has been extensively used as a non-toxic inhibitor of the multienz...

Diels-Alder reactions of halogenated masked o-benzoquinones: synthesis of halogen-substituted bicyclo [2.2. 2] octenones.

Tetrahedron Lett. 50(7) , 773-775, (2009)