5-Chloro-2-Fluorotoluene
Names
[ CAS No. ]:
452-66-4
[ Name ]:
5-Chloro-2-Fluorotoluene
[Synonym ]:
4-Chloro-1-fluoro-2-methylbenzene
5-Chloro-2-Fluorotoluene
EINECS 207-204-0
Benzene, 4-chloro-1-fluoro-2-methyl-
MFCD00018504
4-Chlor-1-fluor-2-methylbenzol
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
162.7±20.0 °C at 760 mmHg
[ Molecular Formula ]:
C7H6ClF
[ Molecular Weight ]:
144.574
[ Flash Point ]:
52.5±7.3 °C
[ Exact Mass ]:
144.014206
[ LogP ]:
3.28
[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.502
[ Storage condition ]:
Flammables area
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R10;R36/37/38
[ Safety Phrases ]:
S16-S26-S36/37/39-S37/39
[ RIDADR ]:
UN 1993 3/PG 3
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
2903999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Org. Lett. , (2015)
The palladium-catalyzed direct cross-coupling of a range of organic chlorides and bromides with the bifunctional C(sp(3))-(trimethylsilyl)methyllithium reagent is reported. The use of Pd-PEPPSI-IPent ...
Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides.J. Med. Chem. 34 , 3098, (1991)
For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. Recent results from several researc...
Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly potent and long-lasting calcium antagonists.Chem. Pharm. Bull. 40 , 2049, (1992)
New 1,4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethyl-propyl ester were synthesized and their antihypertensive activities were ex...