4-Fluorophenacyl chloride
Names
[ CAS No. ]:
456-04-2
[ Name ]:
4-Fluorophenacyl chloride
[Synonym ]:
α-Chloro-p-fluoroacetophenone
G1VR DF
α-Chloro-para-fluoroacetophenone
2-chloro-4'-fluoro-acetophenone
α-Chloro-4'-fluoroacetophenone
A-CHLORO-4-FLUOROACETOPHENONE
p-Fluorophenacyl chloride
Fluorophenacylchloride
MFCD00011652
2-Chloro-4′-fluoroacetophenone
Ethanone, 2-chloro-1-(4-fluorophenyl)-
4-Fluorchloracetophenone
2-Chloro-1-(4-fluorophenyl)ethan-1-one
Ethanone, 2-chloro-1-(4-fluorophenyl)- (9CI)
2-Chloro-4'-fluoroacetophenone
Acetophenone, α-chloro-4'-fluoro-
EINECS 207-256-4
2-Chloro-4‘-fluoroacetophenone
Acetophenone, 2-chloro-4'-fluoro-
2-Chloro-4'-fluoroac
4-Fluorophenacyl chloride
2-Chloro-1-(4-fluorophenyl)ethanone
ω-Chloro-4'-fluoroacetophenone
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
247.0±15.0 °C at 760 mmHg
[ Melting Point ]:
47-50 °C(lit.)
[ Molecular Formula ]:
C8H6ClFO
[ Molecular Weight ]:
172.584
[ Flash Point ]:
103.2±20.4 °C
[ Exact Mass ]:
172.009125
[ PSA ]:
17.07000
[ LogP ]:
1.90
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.514
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM6550000
- CHEMICAL NAME :
- Acetophenone, 2-chloro-4'-fluoro-
- CAS REGISTRY NUMBER :
- 456-04-2
- BEILSTEIN REFERENCE NO. :
- 0637860
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H6-Cl-F-O
- MOLECULAR WEIGHT :
- 172.59
- WISWESSER LINE NOTATION :
- G1VR DF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 89 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05172
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
T:Toxic;Xi:Irritant;
[ Risk Phrases ]:
R23/25;R34;R36/37/38
[ Safety Phrases ]:
S26-S28-S45-S36/37/39
[ RIDADR ]:
UN 3261 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AM6550000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2914700090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Chem. Res. Toxicol. 20(1) , 149-54, (2007)
S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid...
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.Bioorg. Med. Chem. 17(4) , 1716-23, (2009)
Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous re...
Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.Contact Dermatitis 34(6) , 434-5, (1996)