4-Fluorobenzyl bromide
Names
[ CAS No. ]:
459-46-1
[ Name ]:
4-Fluorobenzyl bromide
[Synonym ]:
FR D1E
EINECS 207-291-5
MFCD00000359
1-(Bromomethyl)-4-fluorobenzene
p-Fluorobenzyl bromide
4-Fluorobenzyl bromide
Benzene, 1-(bromomethyl)-4-fluoro-
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
195.9±15.0 °C at 760 mmHg
[ Molecular Formula ]:
C7H6BrF
[ Molecular Weight ]:
189.025
[ Flash Point ]:
74.8±15.3 °C
[ Exact Mass ]:
187.963684
[ LogP ]:
2.97
[ Vapour Pressure ]:
0.6±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.544
MSDS
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R34;R36
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 3265 8/PG 2
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2903999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. 14(16) , 5742-55, (2006)
Because of its essential role in HIV replication and lack of human counterpart, HIV integrase is an attractive target for the development of novel anti-AIDS agents. Among the recently developed integr...
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.ChemMedChem 4(8) , 1311-6, (2009)
The cellular protein lens epithelium-derived growth factor, or transcriptional coactivator p75 (LEDGF/p75), plays a crucial role in HIV integration. The protein-protein interactions (PPIs) between HIV...
Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.J. Med. Chem. 51(24) , 8057-67, (2008)
Imaging of programmed cell death (apoptosis) is important in the assessment of therapeutic response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The executioner caspases 3...