Ethyl fluoroacetate

Names

[ CAS No. ]:
459-72-3

[ Name ]:
Ethyl fluoroacetate

[Synonym ]:
Acetic acid, 2-fluoro-, ethyl ester
Ethyl fluoroacetate
EINECS 207-297-8
Ethyl 2-fluoroacetate
MFCD00000450
Fluoroacetic Acid Ethyl Ester

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
118.0±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₇FO₂

[ Molecular Weight ]:
106.096

[ Flash Point ]:
30.0±0.0 °C

[ Exact Mass ]:
106.043007

[ PSA ]:
26.30000

[ LogP ]:
0.37

[ Vapour Pressure ]:
17.0±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.354

[ Water Solubility ]:
DECOMPOSES

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH7175000

CHEMICAL NAME :: Acetic acid, fluoro-, ethyl ester

CAS REGISTRY NUMBER :: 459-72-3

BEILSTEIN REFERENCE NO. :: 1743761

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H7-F-O2

MOLECULAR WEIGHT :: 106.11

WISWESSER LINE NOTATION :: F1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 11FYAN "Fluorine Chemistry, Volume III. Biological Effects of Organic Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963 Volume(issue)/page/year: 3,59,1963 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H300-H400

[ Precautionary Statements ]:
P264-P273-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R10;R26/27/28

[ Safety Phrases ]:
S13-S36/37/39-S45-S28A-S16

[ RIDADR ]:
UN 2929 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AH7175000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
29159080

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy-4-fluoromuscarines.

J. Med. Chem. 35(17) , 3102-10, (1992)

Four isomers of [(4-fluoro-5-methyl-tetrahydrofuran-2-yl)methyl]trimethylammonium iodide (4-deoxy-4-fluoro-muscarines) were prepared in enantiomerically and diastereomerically pure form from (S)-(-)-m...

A Convenient Synthesis of Ethyl(Diethoxyphosphoryl) fluoroacetate from Ethyl Fluoroacetate. Elkik E and Imbeaux M.

Synthesis 1989(11) , 861-62, (1989)

Reactivity of ethyl acetate and its derivatives toward ammonolysis: ramifications for ammonolysis-based microencapsulation process. Chung Y, et al.

Polym. Adv. Technol. 20(10) , 785-94, (2009)