Dicyanodiamide
Names
[ CAS No. ]:
461-58-5
[ Name ]:
Dicyanodiamide
[Synonym ]:
Metformin impurity A
2-cyanoguanidine
Metformin Related Compound A
EINECS 207-312-8
Dicyandiamide
MFCD00008066
Cyanoguanidine
Metformin Impurity 1
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
229.8±23.0 °C at 760 mmHg
[ Melting Point ]:
208-211 °C(lit.)
[ Molecular Formula ]:
C2H4N4
[ Molecular Weight ]:
84.080
[ Flash Point ]:
92.8±22.6 °C
[ Exact Mass ]:
84.043594
[ PSA ]:
85.69000
[ LogP ]:
-1.15
[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.612
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.
[ Water Solubility ]:
32 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ME9950000
- CHEMICAL NAME :
- Guanidine, cyano-
- CAS REGISTRY NUMBER :
- 461-58-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C2-H4-N4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,17,1953
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,1325,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 8,329,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 8,329,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 273 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (109),61,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83038 No. of Facilities: 720 (estimated) No. of Industries: 27 No. of Occupations: 55 No. of Employees: 19281 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83038 No. of Facilities: 1639 (estimated) No. of Industries: 48 No. of Occupations: 50 No. of Employees: 35475 (estimated) No. of Female Employees: 7043 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
ME9950000
[ HS Code ]:
29262000
Customs
[ HS Code ]: 29262000
Articles
J. Chromatogr. A. 1373 , 106-13, (2014)
A method for the rapid quantification of 9 potential nitrogen-rich economic adulterants (dicyandiamide, urea, biuret, cyromazine, amidinourea, ammeline, amidinourea, melamine, and cyanuric acid) in fi...
A rod-packing microporous hydrogen-bonded organic framework for highly selective separation of C2H2/CO2 at room temperature.Angew. Chem. Int. Ed. Engl. 54(2) , 574-7, (2015)
Self-assembly of a trigonal building subunit with diaminotriazines (DAT) functional groups leads to a unique rod-packing 3D microporous hydrogen-bonded organic framework (HOF-3). This material shows p...
Confirmation of co-denitrification in grazed grassland.Sci. Rep. 5 , 17361, (2015)
Pasture-based livestock systems are often associated with losses of reactive forms of nitrogen (N) to the environment. Research has focused on losses to air and water due to the health, economic and e...