Eact

Names

[ Name ]:
Eact

[Synonym ]:
MFCD03115431

Biological Activity

[Description]:

Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1].

[In Vitro]

Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1].

[References]

[1]. Liu S, et al. Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br J Pharmacol. 2016 Apr;173(7):1208-18.

Chemical & Physical Properties

[ Density]:
1.237±0.06 g/cm3(Predicted)

[ Boiling Point ]:
595.9±60.0 ℃(Predicted)

[ Molecular Formula ]:
C₂₂H₂₄N₂O₅S

[ Molecular Weight ]:
428.50100

[ Exact Mass ]:
428.14100

[ PSA ]:
98.36000

[ LogP ]:
4.12910

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport