N-Hydroxypiperidine

Names

[ CAS No. ]:
4801-58-5

[ Name ]:
N-Hydroxypiperidine

[Synonym ]:
1-HYDROXYPIPERIDINE
EINECS 225-362-9
MFCD00038048
Piperidin-1-ol

Chemical & Physical Properties

[ Density]:
1.07g/cm3

[ Boiling Point ]:
175.7ºC at 760 mmHg

[ Melting Point ]:
37-39ºC

[ Molecular Formula ]:
C₅H₁₁NO

[ Molecular Weight ]:
101.14700

[ Flash Point ]:
78ºC

[ Exact Mass ]:
101.08400

[ PSA ]:
23.47000

[ LogP ]:
0.79940

[ Index of Refraction ]:
1.508

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN6829550

CHEMICAL NAME :: 1-Piperidinol

CAS REGISTRY NUMBER :: 4801-58-5

BEILSTEIN REFERENCE NO. :: 0102726

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H11-N-O

MOLECULAR WEIGHT :: 101.17

WISWESSER LINE NOTATION :: T6NTJ AQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05185

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ RTECS ]:
TN6829550

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

PLoS ONE 7(12) , e52790, (2012)

Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the ...

Biological N-oxidation of piperidine in vitro.

Zhongguo Yao Li Xue Bao 10(3) , 252-6, (1989)

The biological N-oxidation of piperidine, a pharmacologically active biogenic amine of mammals and human beings, was studied in vitro. After incubation of piperidine-HCl in a fortified rat liver micro...

On the effect of thalidomide on Mycobacterium avium subspecies paratuberculosis in culture.

Int. J. Infect. Dis. 13(5) , e254-63, (2009)

Without known mechanisms of action, thalidomide is used to treat a variety of non-malignant 'idiopathic' diseases. There is increasing concern that Mycobacterium avium subspecies paratuberculosis (MAP...