captodiame
Names
[ CAS No. ]:
486-17-9
[ Name ]:
captodiame
[Synonym ]:
N,N-Dimethyl-2-(4-butylmercapto-benzhydrylmercapto)-ethylamin
Captodiamin
Kaptodiamin [Czech]
Captodiamine
[2-(4-Butylmercapto-benzhydrylmercapto)-aethyl]-dimethyl-amin
Captodramine
Captodiame
Covatin
Captodramin
Captodiamum [INN-Latin]
Captodiamo [INN-Spanish]
[2-(4-butylsulfanyl-benzhydrylmercapto)-ethyl]-dimethyl-amine
1-(4-Butylmercapto-benzhydrylmercapto)-2-dimethylamino-ethan
Covatix
Chemical & Physical Properties
[ Density]:
1.08g/cm3
[ Boiling Point ]:
466.1ºC at 760mmHg
[ Molecular Formula ]:
C21H29NS2
[ Molecular Weight ]:
359.59200
[ Flash Point ]:
235.7ºC
[ Exact Mass ]:
359.17400
[ PSA ]:
53.84000
[ LogP ]:
5.96300
[ Vapour Pressure ]:
7.26E-09mmHg at 25°C
[ Index of Refraction ]:
1.596
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KQ8563000
- CHEMICAL NAME :
- Ethylamine, 2-((p-(butylthio)-alpha-phenylbenzyl)thio)-N,N-dimeth yl-
- CAS REGISTRY NUMBER :
- 486-17-9
- BEILSTEIN REFERENCE NO. :
- 2625367
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H29-N-S2
- MOLECULAR WEIGHT :
- 359.63
- WISWESSER LINE NOTATION :
- 4SR DYR&S2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 343 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1630 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 116 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 108,201,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,440,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 12,448,1963