MAC13772

Names

[ Name ]:
MAC13772

[Synonym ]:
2-[(2-Nitrophenyl)thio]acetic Acid Hydrazide
2-(2-Nitro-phenylmercapto)-essigsaeure-hydrazid
2-(2-nitrophenylthio)acetohydrazide
2-[(2-nitrophenyl)thio]ethanohydrazide

Biological Activity

[Description]:

MAC13772 is a potent inhibitor of the enzyme BioA (IC50=250 nM), the antepenultimate step in biotin biosynthesis. MAC13772 is a novel antibacterial compound[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 250 nM (BioA)[1]

[References]

[1]. Zlitni S, et al. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol. 2013 Dec;9(12):796-804.

Chemical & Physical Properties

[ Density]:
1.44 g/cm3

[ Boiling Point ]:
461ºC at 760mmHg

[ Molecular Formula ]:
C₈H₉N₃O₃S

[ Molecular Weight ]:
227.24000

[ Flash Point ]:
232.6ºC

[ Exact Mass ]:
227.03600

[ PSA ]:
126.24000

[ LogP ]:
2.29120

[ Index of Refraction ]:
1.649

MAC13772

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds