epi-Inositol

Names

[ CAS No. ]:
488-58-4

[ Name ]:
epi-Inositol

[Synonym ]:
1,2,3,4,5,6-Cyclohexanehexol, (1α,2α,3α,4α,5α,6β)-
(1R,2R,3r,4S,5S,6s)-1,2,3,4,5,6-Cyclohexanehexol
(1R,2R,3r,4S,5S,6s)-Cyclohexane-1,2,3,4,5,6-hexol
epi-Inositol
1,2,3,4,5/6-Inositol

Biological Activity

[Description]:

epi-Inositol is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ethanol Consumption[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Viola A, et al. High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism. MAGMA. 2004 Sep;17(1):47-61.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
291.3±40.0 °C at 760 mmHg

[ Melting Point ]:
304°C(dec.)(lit.)

[ Molecular Formula ]:
C₆H₁₂O₆

[ Molecular Weight ]:
180.156

[ Flash Point ]:
143.4±21.9 °C

[ Exact Mass ]:
180.063385

[ PSA ]:
121.38000

[ LogP ]:
-2.11

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.784

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2906199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906199090

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Synthesis of allo- and epi-inositol via the NHC-catalyzed carbocyclization of carbohydrate-derived dialdehydes.

J. Org. Chem. 79(11) , 5088-96, (2014)

A synthesis of carbocyclic sugars from carbohydrate-derived dialdehydes using organocatalysis has been developed. Sorbitol, mannitol, and galactitol were converted via 1,6-tritylation, perbenzylation ...

Synthesis of phosphatidylinositols having various inositol stereoisomers by engineered phospholipase D.

J. Biosci. Bioeng. 109(4) , 337-40, (2010)

Phospholipase D-mediated synthesis of phosphatidylinositols having various inositol stereoisomers was studied. Seven inositol stereoisomers were tested, all of which were found to be substrates of the...

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

Nat. Med. 12(7) , 801-8, (2006)

When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain...