ORM-10103

Names

[ Name ]:
ORM-10103

Biological Activity

[Description]:

ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

IC50: 55 (NCX -80 mV ), 67 nM (NCX 20 mV)[2]

[References]

[1]. Jost N, et al. ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart. Br J Pharmacol. 2013 Oct;170(4):768-78.

[2]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₆N₂O₄

[ Molecular Weight ]:
348.35

[ Exact Mass ]:
348.11100

[ PSA ]:
77.17000

[ LogP ]:
5.37160

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII