melarsoprol

Names

[ CAS No. ]:
494-79-1

[ Name ]:
melarsoprol

[Synonym ]:
Mel B
melarsenoxide-BAL
Melarsoprol
Melarsoprolum [INN-Latin]
Melarsoprolum
2-(p-(4,6-Diamino-s-triazin-2-ylamino)phenyl)-1,3,2-dithiarsolane-4-methanol
{2-[4-(4,6-diamino-[1,3,5]triazin-2-ylamino)-phenyl]-[1,3,2]dithiarsolan-4-yl}-methanol
EINECS 207-793-4
Melarsenoxid-BAL
1,3,2-Dithiarsolane-4-methanol,2-(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)
Arsobal

Biological Activity

[Description]:

Melarsoprol (Arsobal), a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Z Gregus, et al. Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol. Biochem Pharmacol. 2000 Jun 1;59(11):1375-85.

Chemical & Physical Properties

[ Boiling Point ]:
688.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₅AsN₆OS₂

[ Molecular Weight ]:
398.33900

[ Flash Point ]:
370.2ºC

[ Exact Mass ]:
397.99600

[ PSA ]:
173.57000

[ LogP ]:
1.55110

[ Vapour Pressure ]:
6.7E-20mmHg at 25°C

melarsoprol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds