3,4-Diaminotoluene

Names

[ CAS No. ]:
496-72-0

[ Name ]:
3,4-Diaminotoluene

[Synonym ]:
1,2-Benzenediamine, 4-methyl-
3,4-toluenediamine
EINECS 207-826-2
4-Methyl-1,2-benzenediamine
4-methylbenzene-1,2-diamine
MFCD00007728
3,4-Diaminotoluene
Tolylene-3,4-diamine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
262.3±20.0 °C at 760 mmHg

[ Melting Point ]:
87-89 °C(lit.)

[ Molecular Formula ]:
C₇H₁₀N₂

[ Molecular Weight ]:
122.168

[ Flash Point ]:
132.1±21.3 °C

[ Exact Mass ]:
122.084396

[ PSA ]:
52.04000

[ LogP ]:
0.51

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
16 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9820000

CHEMICAL NAME :: Toluene-3,4-diamine

CAS REGISTRY NUMBER :: 496-72-0

BEILSTEIN REFERENCE NO. :: 0507965

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H10-N2

MOLECULAR WEIGHT :: 122.19

WISWESSER LINE NOTATION :: ZR BZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,75,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36;R40;R52/53

[ Safety Phrases ]:
S26-S37/39-S61-S36/37/39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
2

[ RTECS ]:
XS9820000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29215119

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.

Teratology 24(3) , 253-65, (1981)

Pregnant outbred albino (CD-1) mice were given 2-nitro-p-phenylenediamine (2NPPD; 32-256 mg/kg/day), 4-nitro-o-phenylenediamine (4NOPD; 16-1024 mg/kg/day) or 2,5-toluenediamine sulfate (2,5TDS; 16-64 ...

Effect of 4 toluene diamine isomers on murine testicular DNA synthesis.

Mutat. Res. 91(1) , 75-9, (1981)

Teratogenesis study of o-toluenediamine in rats and rabbits.

Toxicol. Appl. Pharmacol. 71(3) , 323-9, (1983)

o-Toluenediamine in corn oil was administered po to Sprague-Dawley rats at dosages of 10, 30, 100, or 300 mg/kg body wt/day during Days 6 through 15 of gestation. All animals were killed on Day 20 of ...