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4-Hydroxybutanoic acid sodium salt

Names

[ CAS No. ]:
502-85-2

[ Name ]:
4-Hydroxybutanoic acid sodium salt

[Synonym ]:
GHB
Sodium 4-hydroxybutanoate
Xyrem
4-Hydroxybutyrate sodium
Butanoic acid, 4-hydroxy-, sodium salt (1:1)
Sodium Oxybate
GHB SODIUM SALT
Butanoic acid, 4-hydroxy-, monosodium salt
Butanoic acid, 4-hydroxy-, sodium salt
gammaoh
MFCD00004402
γ-OH
SODIUM 4-HYDROXYBUTYRATE
γ-Hydroxybutyrate sodium
wy-3478
4-Hydroxybutanoic Acid Monosodium Salt
4-Hydroxybutyric acid monosodium salt
Sodium γ-hydroxybutyrate
Butyric acid, 4-hydroxy-, monosodium salt (8CI)
somsanit
γ-Hydroxybutyric acid monosodium salt
Butyric acid, 4-hydroxy-, sodium salt
Butyric acid, 4-hydroxy-, monosodium salt
Sodium Oxybate [USAN]
4-Hydroxybutyric acid sodium salt
EINECS 207-953-3

Chemical & Physical Properties

[ Boiling Point ]:
295.6ºC at 760mmHg

[ Melting Point ]:
145-146ºC

[ Molecular Formula ]:
C4H8NaO3+

[ Molecular Weight ]:
126.086

[ Flash Point ]:
146.8ºC

[ Exact Mass ]:
126.029289

[ PSA ]:
57.53000

[ Storage condition ]:
Controlled Substance, -20?C Freezer

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ET4750000
CHEMICAL NAME :
Butyric acid, 4-hydroxy-, sodium salt
CAS REGISTRY NUMBER :
502-85-2
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C4-H7-O3.Na
MOLECULAR WEIGHT :
126.10
WISWESSER LINE NOTATION :
Q3VO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - coma Gastrointestinal - nausea or vomiting
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 9,321,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,714,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 32,375,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - alteration of classical conditioning Skin and Appendages - hair
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,30,1967 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
40 mg/kg
SEX/DURATION :
female 68 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 100,72,1968

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK Germany ]:
2

[ RTECS ]:
ET4750000

[ HS Code ]:
2918199090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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