CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC

Names

[ Name ]:
CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC

[Synonym ]:
8-Azabicyclo(3.2.1)octane-2-carboxylic acid,8-methyl-3-phenyl-,methyl ester,(1R-(exo,exo))
WIN35,065-2
methyl <1R-(exo,exo)>-8-methyl-3-phenyl-8-azabicyclo<3.2.1>octane-2-carboxylate
[1R-(exo,exo)]-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester

Chemical & Physical Properties

[ Density]:
1.099g/cm3

[ Boiling Point ]:
350.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₇NO₈

[ Molecular Weight ]:
409.43000

[ Flash Point ]:
121.3ºC

[ Exact Mass ]:
409.17400

[ PSA ]:
144.60000

[ LogP ]:
0.24120

[ Index of Refraction ]:
1.54

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL5603110

CHEMICAL NAME :: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 8-methyl-3-phenyl-, methyl ester, (1R-(exo,exo))-

CAS REGISTRY NUMBER :: 50372-80-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H21-N-O2

MOLECULAR WEIGHT :: 259.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,1260,1973

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

New, potent cocaine analogs: ligand binding and transport studies in rat striatum.

Eur. J. Pharmacol. 184(2-3) , 329-32, (1990)

Two potent cocaine analogs have been developed that have the highest known affinities for the cocaine binding site in rat striatum. Both 3 beta-(4-chlorophenyl)- (RTI-COC-31) and 3 beta-(4-methylpheny...

Saturable (3H)cocaine binding in central nervous system of mouse.

Life Sci. 27(12) , 1055-62, (1980)

Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.

J. Med. Chem. 40(8) , 1247-51, (1997)

2beta,3beta-Diphenyl-(5), 2alpha,3alpha-diphenyl-(6), and 2alpha,3beta-diphenyltropane (3) as well as 2,3-diphenyltrop-2-ene (4) were prepared in racemic form and assayed for inhibition of radioligand...