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2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione

Names

[ CAS No. ]:
5054-59-1

[ Name ]:
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-
2-(2,6-Dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
E3 ligase Ligand 2
4-Hydroxythalidomide
Pomalidomide Impurity 1

Biological Activity

[Description]:

E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.

[Related Catalog]:

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Research Areas >> Cancer

[Target]

Ligand for E3 Ligase[1]


[In Vitro]

Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].

[References]

[1]. Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.


[Related Small Molecules]

E3 ligase Ligand 1 | TC E3 5031 | VH 298 | Thalidomide fluoride | E3 ligase Ligand 5 | E3 ligase Ligand 6 | TNF-α-IN-1

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
568.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H10N2O5

[ Molecular Weight ]:
274.229

[ Flash Point ]:
297.5±28.7 °C

[ Exact Mass ]:
274.058960

[ LogP ]:
-0.20

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2-8℃

Related Compounds