Pyrrolidine,1,1'-(2-butyne-1,4-diyl)bis-
Names
[ CAS No. ]:
51-73-0
[ Name ]:
Pyrrolidine,1,1'-(2-butyne-1,4-diyl)bis-
[Synonym ]:
Tremorin
1,4-Dipyrrolidine-2-butyne
Tremorine
1,1'-but-2-yne-1,4-diyl-bis-pyrrolidine
1,4-dipyrrolidino-but-2-yne
1,4-Dipyrrolidino-2-butyne
Biofermin
1,4-Dipyrrolidino-but-2-in
1,4-Dipyrrolidino-2-butin
1,4-Dipyrrolidinyl-2-butyne
Chemical & Physical Properties
[ Density]:
1.014g/cm3
[ Boiling Point ]:
285.6ºC at 760mmHg
[ Molecular Formula ]:
C12H20N2
[ Molecular Weight ]:
192.30100
[ Flash Point ]:
118.4ºC
[ Exact Mass ]:
192.16300
[ PSA ]:
6.48000
[ LogP ]:
1.05720
[ Index of Refraction ]:
1.531
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY0175000
- CHEMICAL NAME :
- Pyrrolidine, 1,1'-(2-butynylene)di-
- CAS REGISTRY NUMBER :
- 51-73-0
- BEILSTEIN REFERENCE NO. :
- 0006119
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C12-H20-N2
- MOLECULAR WEIGHT :
- 192.34
- WISWESSER LINE NOTATION :
- T5NTJ A2UU2- AT5NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 58 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(3),83S,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#12070
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,447,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
Safety Information
[ RIDADR ]:
UN 2810
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%