Cystamine

Names

[ CAS No. ]:
51-85-4

[ Name ]:
Cystamine

[Synonym ]:
diaminosulphonate
NH2CH2CH2NHCH2CH2SO3Na
cysteamine disulfide
2-[(2-aminoethyl)amino]-ethanesulfonic acid monosodium salt
SodiuM 2-[(2-aMinoethyl)aMino]ethanesulphona
2-(2-aminoethyldisulfanyl)ethanamine
Natrium-2-[(2-aminoethyl)amino]ethansulfonat
N-(2-AMINOETHYL)-3-AMINOETHANESULPHONICACID,SODIUMSALT
2,2'-Disulfanediyldiethanamine
3,4-dithiahexane-1,6-diamine
2-[(2-Aminoethyl)amino]ethane-1-sulfonic acid sodium salt
2-(2-aminoethyldisulfonyl)-ethylamine
Ethanesulfonic acid,2-(2-aminoethyl)amino-,monosodium salt
sodium salt of 2-(2-amino-ethylamino)-ethanesulfonic acid
2-[(2-AMINOETHYL)AMINO]ETHANE SULFONIC ACID SODIUM SALT

Biological Activity

[Description]:

Cystamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.172g/cm3

[ Boiling Point ]:
264.8ºC at 760 mmHg

[ Molecular Formula ]:
C₄H₁₂N₂S₂

[ Molecular Weight ]:
152.28100

[ Flash Point ]:
114ºC

[ Exact Mass ]:
152.04400

[ PSA ]:
102.64000

[ LogP ]:
1.68580

[ Index of Refraction ]:
1.587

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%