(S)-(+)-Ibuprofen

Names

[ Name ]:
(S)-(+)-Ibuprofen

[Synonym ]:
(2S)-2-(4-Isobutylphenyl)propanoic acid
(S)-(+)-4-Isobutyl-α-methylphenylacetic Acid
(S)-2-(4-Isobutylphenyl)propanoic acid
Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αS)-
(+)-(S)-Ibuprofen
(+)-ibuprofen
MFCD00069289
Dexibuprofen
(S)-4-Isobutyl-α-methylphenylacetic acid
(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
(S)-(+)-Ibuprofen
(S)-(+)-2-(4-isobutylphenyl)propanoic acid
d-Ibuprofen
(S)-(+)-4-Isobutyl-Alpha-Methylphenylacetic Acid
Ibuprofen
(S)-(+)-2-(4-Isobutylphenyl)propionic Acid
(S)-a-Methyl-4-(2-methylpropyl)benzeneacetic acid
(S)-ibuprofen
(2S)-2-[4-(2-Methylpropyl)phenyl]propionic acid

Biological Activity

[Description]:

(S)-(+)-Ibuprofen is the S-enantiomer of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
319.6±11.0 °C at 760 mmHg

[ Melting Point ]:
49-53ºC

[ Molecular Formula ]:
C₁₃H₁₈O₂

[ Molecular Weight ]:
206.281

[ Flash Point ]:
216.7±14.4 °C

[ Exact Mass ]:
206.130676

[ PSA ]:
37.30000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.519

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R63

[ Safety Phrases ]:
S36/37-S45

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ Hazard Class ]:
6.1

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.

J. Pharmacol. Exp. Ther. 351(1) , 61-6, (2014)

Esterase hydrolysis of drugs can accelerate their elimination, thereby limiting their efficacy. Polyethylene glycol (PEG) covalently attached to drugs (pegylation) is known to improve the efficiency o...