3,3'-Diethylthiadicarbocyanine iodide

Names

[ CAS No. ]:
514-73-8

[ Name ]:
3,3'-Diethylthiadicarbocyanine iodide

[Synonym ]:
3,3'-diethyl-2,2'-thiadicarbocyanine iodide
PARTEL
MFCD00074829
DELVEX
TELMID
ANELMID
3-ethyl-2-<5-(3-ethyl-2(3H)-benzothiazolidene)-1,3-pentadienyl>benzothiazolium iodide
3,3′-Diethylthiadicarbocyanine iodide
DTDC
EINECS 208-186-7
NETOCYD
DTDCL
DEJO
NK 136
3,3'-diethylthiadicarbocyanine
3,3'-DIETHYLTHIADICARBOCYANINE IODIDE
DTDCI

Biological Activity

[Description]:

Dithiazanine iodide is an effective broad-spectrum anthelmintic. Dithiazanine iodide can be used for the research of trichuriasis, strongyloidiasis, enterobiasis, ascariasis, and hookworm infection. Dithiazanine iodide is also a cyanine dye[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. SWARTZWELDER JC, et al. Dithiazanine, an effective broad-spectrum anthelmintic; results of therapy of trichuriasis, strongyloidiasis, enterobiasis, ascariasis, and hookworm infection. J Am Med Assoc. 1957 Dec 21;165(16):2063-7.

[2]. ABADIE SH, et al. A FATALITY ASSOCIATED WITH DITHIAZANINE IODIDE THERAPY. JAMA. 1965 Apr 26;192:326-7.

Chemical & Physical Properties

[ Melting Point ]:
249ºC

[ Molecular Formula ]:
C₂₃H₂₃IN₂S₂

[ Molecular Weight ]:
518.47700

[ Exact Mass ]:
518.03500

[ PSA ]:
65.29000

[ LogP ]:
2.58000

[ Appearance of Characters ]:
Powder | Green

[ Index of Refraction ]:
1.491

[ Storage condition ]:
Poison room

[ Water Solubility ]:
Soluble in methanol

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7060000

CHEMICAL NAME :: Benzothiazolium, 3-ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3-pe ntadienyl)-, iodide

CAS REGISTRY NUMBER :: 514-73-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H23-N2-S2.I

MOLECULAR WEIGHT :: 518.50

WISWESSER LINE NOTATION :: T56 BNYSJ B2 CU2U2U1- CT56 BK DSJ B2 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,897,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02015

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H315-H319-H335

[ Precautionary Statements ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R28;R36/37/38

[ Safety Phrases ]:
S26-S28-S36/37-S45

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
DL7060000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Articles

Structure-activity relationship of cyanine tau aggregation inhibitors.

J. Med. Chem. 52 , 3539-47, (2009)

A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine...

Three-dimensional fluorescence lifetime tomography.

Med. Phys. 32(4) , 992-1000, (2005)

Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of ...

Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye.

Nucleic Acids Res. 30(2) , E3, (2002)

As the relationship between human genes and various malfunctions and diseases becomes revealed at an ever-increasing pace, the need arises for the development of rapid genetic screening methods for di...