4,6-Dioxoheptanoic acid

Names

[ CAS No. ]:
51568-18-4

[ Name ]:
4,6-Dioxoheptanoic acid

[Synonym ]:
4,6-Dioxoheptanoic acid
Succinylacetone
4,6-DIOXOHEPTANOIC ACID

Biological Activity

[Description]:

4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture[1].

[References]

[1]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.189 g/cm3

[ Boiling Point ]:
318.7ºC at 760 mmHg

[ Melting Point ]:
66-67ºC

[ Molecular Formula ]:
C₇H₁₀O₄

[ Molecular Weight ]:
158.15200

[ Flash Point ]:
160.8ºC

[ Exact Mass ]:
158.05800

[ PSA ]:
71.44000

[ LogP ]:
0.39940

[ Index of Refraction ]:
1.455

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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