(R)-(-)-Epichlorohydrin

Names

[ Name ]:
(R)-(-)-Epichlorohydrin

[Synonym ]:
EINECS 424-280-2
(2R)-(Chloromethyl)oxirane
(R)-Chloromethyloxirane
EPICHLOROHYDRIN, (-)-
(R)-3-Chloropropylene Oxide
(2R)-(-)-2-(Chloromethyl)oxirane
(2R)-(-)-3-Chloro-1,2-propenoxide
(R)-(-)-Epichlorohydrin
(R)-(−)-Epichlorohydrin
(-)-Epichlorohydrin
MFCD00077759
(R)-Epichlorohydrin
()-Chloromethyl oxirane
(2R)-2-(Chloromethyl)oxirane
Oxirane, 2-(chloromethyl)-, (2R)-
(-)-2-(Chloromethyl)oxirane
T3OTJ B1G &&(R)-(-)- Form
(R)-1-Chloro-2,3-epoxypropane

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
116.1±0.0 °C at 760 mmHg

[ Melting Point ]:
-48ºC

[ Molecular Formula ]:
C₃H₅ClO

[ Molecular Weight ]:
92.524

[ Flash Point ]:
33.9±0.0 °C

[ Exact Mass ]:
92.002892

[ PSA ]:
12.53000

[ LogP ]:
0.45

[ Vapour Pressure ]:
22.0±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.444

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR0427000

CHEMICAL NAME :: Oxirane, (chloromethyl)-, (R)-

CAS REGISTRY NUMBER :: 51594-55-9

BEILSTEIN REFERENCE NO. :: 1420785

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C3-H5-Cl-O

MOLECULAR WEIGHT :: 92.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 298,197,1993

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301-H311-H314-H317-H331-H350

[ Precautionary Statements ]:
P201-P261-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R10;R23/24/25;R34;R43;R45

[ Safety Phrases ]:
S45-S53

[ RIDADR ]:
UN 2023

[ WGK Germany ]:
3

[ RTECS ]:
RR0427000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2910900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2910900090

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

The intramolecular asymmetric Pauson-Khand cyclization as a novel and general stereoselective route to benzindene prostacyclins: synthesis of UT-15 (treprostinil).

J. Org. Chem. 69 , 1890, (2004)

A general and novel solution to the synthesis of biologically important stable analogues of prostacyclin PGI(2), namely benzindene prostacyclins, has been achieved via the stereoselective intramolecul...

Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: application to the CCR3 antagonist IS811.

J. Org. Chem. 71 , 8975, (2006)

A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from ...