D(-)-Amethopterin

Names

[ Name ]:
D(-)-Amethopterin

[Synonym ]:
DL-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
DL-Amethopterin
N-(4-{[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)glutamic acid
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
d-methotrexate
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
DL-Methotrexate
DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
DL-4-Amino-N10-methylpteroylglutamic acid
TCMDC-123832
Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
UNII:99ITO15X8S
Einecs 257-482-2
N-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid
D(-)-Amethopterin
Methotrexate Impurity 6

Chemical & Physical Properties

[ Density]:
1.537g/cm3

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C₂₀H₂₂N₈O₅

[ Molecular Weight ]:
454.439

[ Exact Mass ]:
454.171326

[ PSA ]:
210.54000

[ LogP ]:
-0.24

[ Index of Refraction ]:
1.738

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA1224000

CHEMICAL NAME :: Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b enzoyl)-, D-

CAS REGISTRY NUMBER :: 51865-79-3

LAST UPDATED :: 199610

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H22-N8-O5

MOLECULAR WEIGHT :: 454.50

WISWESSER LINE NOTATION :: T66 BN DN GN JNJ CZ EZ H1N1&R DVMYVQ2VQ -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 29,43,1982

Safety Information

[ Risk Phrases ]:
61-46-25-36/37/38-60-23/24/25

[ Safety Phrases ]:
53-45-28A-36/37/39-26-22

[ RIDADR ]:
UN 1544 6.1/PG 3

[ HS Code ]:
29335995

Customs

[ HS Code ]: 29335995