2-Chloro-5-(trifluoromethyl)pyridine

Names

[ Name ]:
2-Chloro-5-(trifluoromethyl)pyridine

[Synonym ]:
2-Chloro-5-Trifluoromethylpyridine
EINECS 257-856-5
Pyridine, 2-chloro-5-(trifluoromethyl)-
2-Chloro-5-(trifluoromethyl)pyridine
T6NJ BG EXFFF
MFCD00042225

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
171.6±35.0 °C at 760 mmHg

[ Melting Point ]:
32-34 °C(lit.)

[ Molecular Formula ]:
C₆H₃ClF₃N

[ Molecular Weight ]:
181.543

[ Flash Point ]:
57.6±25.9 °C

[ Exact Mass ]:
180.990616

[ PSA ]:
12.89000

[ LogP ]:
2.44

[ Vapour Pressure ]:
1.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.447

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7530000

CHEMICAL NAME :: Pyridine, 2-chloro-5-(trifluoromethyl)-

CAS REGISTRY NUMBER :: 52334-81-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H3-Cl-F3-N

MOLECULAR WEIGHT :: 181.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/m3/6H/4W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5500 mg/kg/21D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 800 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,57,1993

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
US7530000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Three chloro (trifluoromethyl) pyridines as model substrates for regioexhaustive functionalization. Cottet F and Schlosser M.

European J. Org. Chem. 18 , 3793-98, (2004)