5,12-Dihydroquinoxalino[2,3-b]quinoxaline

Names

[ CAS No. ]:
531-46-4

[ Name ]:
5,12-Dihydroquinoxalino[2,3-b]quinoxaline

[Synonym ]:
5,12-Dihydroquinoxalino[2,3-b]quinoxaline
Quinoxalino[2,3-b]quinoxaline, 5,12-dihydro-
5,11-dihydro-5,6,11,12-tetraazanaphthacene

Biological Activity

[Description]:

Fluoflavine (ML-090) is a selective NOX1 inhibitor with an IC50 of 90 nM. Fluoflavine has >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50>10 μM). ML-090 has an IC50 of 360 nM in HEK293 cells[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. SJ Brown, et al. Probe Report for NOX1 Inhibitors.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
477.5±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₀N₄

[ Molecular Weight ]:
234.256

[ Flash Point ]:
242.6±25.4 °C

[ Exact Mass ]:
234.090546

[ PSA ]:
57.36000

[ LogP ]:
2.93

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.711

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%