DiOC7(3)

Names

[ Name ]:
DiOC7(3)

[Synonym ]:
BENZOXAZOLIUM,3-HEPTYL-2-[3-(3-HEPTYL-2(3H)-BENZOXAZOLYLIDENE)-1-PROPENYL]-,IODIDE
MFCD00274413
D 378
3-HEPTYL-2-((E)-3-[3-HEPTYL-1,3-BENZOXAZOL-2(3H)-YLIDENE]-1-PROPENYL)-1,3-BENZOXAZOL-3-IUM IODIDE
3,3''-DIHEPTYLOXACARBOCYANINE IODIDE [DIOC7(3)]
3,3-diheptyloxacarboxycyanine iodide
DiOC7(3) [3,3'-Diheptyloxacarbocyanine iodide]
DIOC7(3)

Biological Activity

[Description]:

DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

Identification for tumour vasculature (frozen section): Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1]. 1. The dye is administered to murine via lateral tail vein injection at a dose of 1 mg/kg/ in 50 μL volume. 2. Animals are killed 5 min after dye administration, and tumors are immediately excised and frozen at - 20°C. 3. Frozen sections 10 μm in thickness are rewarmed to room temperature, allowed to air dry. 4. Image using a microscope with 100W mercury lamp illumination and an epifluorescence condenser (excited at 430-490 nm, emitted at 510-520 nm.

[References]

[1]. M J Trotter, et al. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. Br J Cancer. 1989 May;59(5):706-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₄₁IN₂O₂

[ Molecular Weight ]:
600.57400

[ Exact Mass ]:
600.22100

[ PSA ]:
35.09000

[ LogP ]:
4.98780

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H335-H360

[ Precautionary Statements ]:
P201-P261-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R61;R36/37/38

[ Safety Phrases ]:
S53

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Tissue penetration and activity of camptothecins in solid tumor xenografts.

Mol. Cancer Ther. 13(11) , 2727-37, (2014)

The ability of a panel of camptothecin derivatives to access the tumor compartment was evaluated to determine the mechanisms by which the architecture of solid tumors may act to limit their activity. ...

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours.

Br. J. Cancer 59 , 706, (1989)

An intravenously administered fluorescent carbocyanine dye, DiOC7(3), has been evaluated for use in conjunction with Hoechst 33342 as a marker of murine tumour vasculature. DiOC7(3) stains cells immed...

Pontentiometric cyanine dyes are sensitive probes for mitochondria in intact plant cells : kinetin enhances mitochondrial fluorescence.

Plant Physiol. 84 , 1385, (1987)

Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in ...