2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide
Names
[ CAS No. ]:
53859-37-3
[ Name ]:
2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide
[Synonym ]:
Dechlorcyclophosphamide
B 516
N,N-Diethylcyclophosphamide
Didechlorocyclophosphamide
ASTA 7019
n,n-diethyl-1,3,2-oxazaphosphinan-2-amine 2-oxide
ASTA B 516
Chemical & Physical Properties
[ Density]:
1.11g/cm3
[ Boiling Point ]:
249ºC at 760mmHg
[ Molecular Formula ]:
C7H17N2O2P
[ Molecular Weight ]:
192.19600
[ Flash Point ]:
104.4ºC
[ Exact Mass ]:
192.10300
[ PSA ]:
51.38000
[ LogP ]:
1.77500
[ Index of Refraction ]:
1.473
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RP5788700
- CHEMICAL NAME :
- 2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,N-diethyl-, 2-oxide
- CAS REGISTRY NUMBER :
- 53859-37-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C7-H17-N2-O2-P
- MOLECULAR WEIGHT :
- 192.23
- WISWESSER LINE NOTATION :
- T6MPOTJ BO BN2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Bird - chicken Cells - not otherwise specified
- DOSE/DURATION :
- 211 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,115,1992
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%