Estr-4-en-3-one,17-[[[(2-chloroethyl)nitrosoamino]carbonyl]oxy]-, (17b)- (9CI)
Names
[ CAS No. ]:
54025-36-4
[ Name ]:
Estr-4-en-3-one,17-[[[(2-chloroethyl)nitrosoamino]carbonyl]oxy]-, (17b)- (9CI)
[Synonym ]:
19-nortestosterone nitrosocarbamate
Chemical & Physical Properties
[ Density]:
1.43g/cm3
[ Boiling Point ]:
529.4ºC at 760mmHg
[ Molecular Formula ]:
C21H29ClN2O4
[ Molecular Weight ]:
408.91900
[ Flash Point ]:
274ºC
[ Exact Mass ]:
408.18200
[ PSA ]:
76.04000
[ LogP ]:
4.85560
[ Index of Refraction ]:
1.661
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7962400
- CHEMICAL NAME :
- Estr-4-en-3-one, 17-((((2-chloroethyl)nitrosoamino)carbonyl)oxy)-, (17-beta)-
- CAS REGISTRY NUMBER :
- 54025-36-4
- LAST UPDATED :
- 198602
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H29-Cl-N2-O4
- MOLECULAR WEIGHT :
- 408.97
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2190 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1630 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,290,1981