Fenbendazole sulfone

Names

[ Name ]:
Fenbendazole sulfone

[Synonym ]:
fenbendazole sulfone

Biological Activity

[Description]:

Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. M B Petersen, et al. Pharmacokinetics of Fenbendazole Following Intravenous and Oral Administration to Pigs. Am J Vet Res. 2000 May;61(5):573-6.

[2]. David L Brandon, et al. Analysis of Fenbendazole Residues in Bovine Milk by ELISA. J Agric Food Chem. 2002 Oct 9;50(21):5791-6.

Chemical & Physical Properties

[ Density]:
1.486 g/cm3

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₁₅H₁₃N₃O₄S

[ Molecular Weight ]:
331.34600

[ Exact Mass ]:
331.06300

[ PSA ]:
109.53000

[ LogP ]:
3.72780

[ Index of Refraction ]:
1.68

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-38

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Nickel Oxide Nanoparticle-Deposited Silica Composite Solid-Phase Extraction for Benzimidazole Residue Analysis in Milk and Eggs by Liquid Chromatography-Mass Spectrometry.

J. Agric. Food Chem. 64 , 356-63, (2016)

A novel nickel oxide nanoparticle-deposited silica (SiO2@NiO) composite was prepared via liquid-phase deposition (LPD) and then employed as a solid-phase extraction (SPE) sorbent. When the SPE was cou...

Pharmacokinetics of oxfendazole in sheep.

Am. J. Vet. Res. 42(7) , 1143-5, (1981)

Pharmacokinetics of oxfendazole and its sulfone metabolite were determined in 6 sheep. Oxfendazole achieved mean peak plasma concentrations of 0.76 micrograms/ml at 30 hours after oral administration ...

A high performance liquid chromatographic method for the determination of febantel and its major metabolites in lamb plasma.

Biomed. Chromatogr. 7(2) , 78-81, (1993)

A high performance liquid chromatographic (HPLC) method for the determination of the anthelminthic pro-benzimidazole febantel and its major metabolites in lamb plasma has been developed. Samples were ...