α-Aminoadipic acid

Names

[ CAS No. ]:
542-32-5

[ Name ]:
α-Aminoadipic acid

[Synonym ]:
2-Aminohexanedioic acid
2-aminoadipic acid
AAD
DL-2-Aminohexanedioic acid
Hexanedioic acid, 2-amino-, (2R)-
D-2-Aminoadipic Acid
Hexanedioic acid, 2-amino-
α-Amino-adipic acid
.α.-Aminoadipic acid
UNII:1K7B1OED4N
DL-2-Aminoadipic acid
DL-a-aminoadipic acid
a-Aminoadipic acid
(2R)-2-Aminohexanedioic acid
MFCD00063119
(±)-2-Aminoadipic acid
EINECS 208-809-2

Biological Activity

[Description]:

Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123(10):4309-17.

[2]. Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.0±32.0 °C at 760 mmHg

[ Melting Point ]:
196-198ºC

[ Molecular Formula ]:
C₆H₁₁NO₄

[ Molecular Weight ]:
161.156

[ Flash Point ]:
173.9±25.1 °C

[ Exact Mass ]:
161.068802

[ PSA ]:
100.62000

[ LogP ]:
-0.54

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.515

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1852000

CHEMICAL NAME :: Hexanedioic acid, 2-amino-

CAS REGISTRY NUMBER :: 542-32-5

BEILSTEIN REFERENCE NO. :: 1773077

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H11-N-O4

MOLECULAR WEIGHT :: 161.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 5,108,1960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MO1852000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Impact of gluconic fermentation of strawberry using acetic acid bacteria on amino acids and biogenic amines profile.

Food Chem. 178 , 221-8, (2015)

This paper studies the amino acid profile of beverages obtained through the fermentation of strawberry purée by a surface culture using three strains belonging to different acetic acid bacteria specie...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Comparative metabolomics analysis on invigorating blood circulation for herb pair Gui-Hong by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and pattern recognition approach.

J. Pharm. Biomed. Anal. 107 , 456-63, (2015)

The compatibility of Angelicae Sinensis Radix (Danggui, DG) and Flos Carthami (Honghua, HH), a famous herb pair Gui-Hong (GH), can produce synergistic and promoting blood effects. Although some physio...