Palmitoylethanolamide

Names

[ CAS No. ]:
544-31-0

[ Name ]:
Palmitoylethanolamide

[Synonym ]:
Palmitoyl Ethanolamide
Palmitoylethanolamide
palmidrol
EINECS 208-867-9
N-(2-Hydroxyethyl)hexadecanamide
MFCD00020562
Hexadecanamide, N-(2-hydroxyethyl)-
AM 3112

Biological Activity

[Description]:

AM 3112 is an active endogenous compound which can used for preventing virus infection of the respiratory tract.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Infection

[Target]

Human Endogenous Metabolite

[In Vitro]

AM 3112 (Impulsin) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of AM 3112, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. AM 3112 is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which AM 3112 decreased the toxicity of virus in the organism is discussed[1].

[References]

[1]. Lackovic V, et al. Effect of impulsin treatment of interferon production and antiviral resistance of mice. Arch Immunol Ther Exp (Warsz). 1977;25(5):655-61.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
461.5±28.0 °C at 760 mmHg

[ Melting Point ]:
99 °C

[ Molecular Formula ]:
C₁₈H₃₇NO₂

[ Molecular Weight ]:
299.492

[ Flash Point ]:
232.9±24.0 °C

[ Exact Mass ]:
299.282440

[ PSA ]:
49.33000

[ LogP ]:
5.82

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.463

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Interaction of intraocular lenses with fibronectin and human lens epithelial cells: Effect of chemical composition and aging.

J. Biomed. Mater. Res. A 103 , 3843-51, (2015)

The aim of this study is to investigate in vitro interactions between hydrophobic acrylate intraocular lenses (IOLs) and their biological environment. The influence of lens chemical composition and ag...

Gastric bypass in morbid obese patients is associated with reduction in adipose tissue inflammation via N-oleoylethanolamide (OEA)-mediated pathways.

Thromb. Haemost. 113(4) , 838-50, (2015)

Paradoxically, morbid obesity was suggested to protect from cardiovascular co-morbidities as compared to overweight/obese patients. We hypothesise that this paradox could be inferred to modulation of ...

Superparamagnetic core-shells anchored onto graphene oxide grafted with phenylethyl amine as a nano-adsorbent for extraction and enrichment of organophosphorus pesticides from fruit, vegetable and water samples.

J. Chromatogr. A. 1406 , 48-58, (2015)

A novel adsorbent composed of silica coated magnetic microparticles (Fe3O4@SiO2) and graphene oxide (GO) functionalized with phenylethyl amine (PEA) was synthesized and characterized using Fourier tra...