4-methoxy-1,3-benzothiazol-2-amine

Names

[ CAS No. ]:
5464-79-9

[ Name ]:
4-methoxy-1,3-benzothiazol-2-amine

[Synonym ]:
EINECS 226-763-1
MFCD00005792
4-methoxy-1,3-benzothiazol-2-amine
2-Benzothiazolamine, 4-methoxy-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
347.5±34.0 °C at 760 mmHg

[ Melting Point ]:
153-155 °C(lit.)

[ Molecular Formula ]:
C₈H₈N₂OS

[ Molecular Weight ]:
180.227

[ Flash Point ]:
163.9±25.7 °C

[ Exact Mass ]:
180.035736

[ PSA ]:
76.38000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Water Solubility ]:
<0.1 g/100 mL at 19.5 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL2000000

CHEMICAL NAME :: Benzothiazole, 2-amino-4-methoxy-

CAS REGISTRY NUMBER :: 5464-79-9

BEILSTEIN REFERENCE NO. :: 0141363

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H8-N2-O-S

MOLECULAR WEIGHT :: 180.24

WISWESSER LINE NOTATION :: T56 BN DSJ CZ IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,682,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DL2000000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Antibacterial Zn (II) compounds of. Schiff bases derived from some benzothiazoles. Chohan ZH and Supuran CT.

Main Group Met. Chem. 25(5) , 291-296, (2002)

Synthesis of Some New 2-(4-Methoxybenzothiazol-2'-yl amino)-4-(2-chloro-4-trifluoromethylanilino)-6-(substituted thioureido)-1, 3, 5-triazine as Antifungal Agents. Sareen V, et al.

Phosph. Sulfur Relat. Elem. 185(1) , 140-146, (2009)