12-deoxyphorbol 13-phenylacetate 20-acetate

[ Density]:
1.29g/cm3

[ Boiling Point ]:
635.7ºC at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₆O₇

[ Molecular Weight ]:
508.60300

[ Flash Point ]:
204.3ºC

[ Exact Mass ]:
508.24600

[ PSA ]:
110.13000

[ LogP ]:
3.32370

[ Index of Refraction ]:
1.607

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H315-H319-H330-H335

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ RIDADR ]:
UN 2811 6.1 / PGIII

Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase C beta I and mu.

Carcinogenesis 22(2) , 221-31, (2001)

12-O:-tetradecanoylphorbol-13-acetate (TPA) inhibits gap junctional communication in many cell culture systems, but TPA-induced phosphorylation of the gap junction protein connexin43 (Cx43) varies muc...

Protein kinase C modulates insulin action in human skeletal muscle.

Am. J. Physiol. Endocrinol. Metab. 278(3) , E553-62, (2000)

There is good evidence from cell lines and rodents that elevated protein kinase C (PKC) overexpression/activity causes insulin resistance. Therefore, the present study determined the effects of PKC ac...

Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.

J. Cereb. Blood Flow Metab. 30(9) , 1593-7, (2010)

Blood-brain barrier (BBB) P-glycoprotein activity is rapidly reduced by vascular endothelial growth factor (VEGF) acting via Src and by tumor necrosis factor-alpha acting via protein kinase C (PKC)bet...

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