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Necroptosis-IN-3

Names

[ CAS No. ]:
547698-18-0

[ Name ]:
Necroptosis-IN-3

[Synonym ]:
N-(2-Thienylmethyl)cyclohexanecarboxamide
Cyclohexanecarboxamide, N-(2-thienylmethyl)-
MFCD03397171

Biological Activity

[Description]:

Necroptosis-IN-3 (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

Necroptosis[1], 11β-HSD1[2]


[In Vitro]

TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) 抑制 TNF-α 诱导的 FADD 缺陷人 Jurkat T 细胞坏死[1]。 Cell Viability Assay[1] Cell Line: Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α Concentration: 0.030-100 μM Incubation Time: 24 h Result: Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells.

[References]

[1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.

[2]. Nigel Vicker, et al. Compound. Patent US20100120789A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
422.4±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H17NOS

[ Molecular Weight ]:
223.34

[ Flash Point ]:
209.3±22.9 °C

[ Exact Mass ]:
223.103088

[ LogP ]:
2.48

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.557

Related Compounds