2-(3,3-diphenylpropyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine

Names

[ Name ]:
2-(3,3-diphenylpropyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine

[Synonym ]:
Octahydro-2-(3,3-diphenylpropyl)-2H-pyrido(1,2-a)pyrazine
2-(3,3-diphenylpropyl)octahydro-2h-pyrido[1,2-a]pyrazine
2H-Pyrido(1,2-a)pyrazine,octahydro-2-(3,3-diphenylpropyl)
N,N,1-Trimethyl-3,3-diphenylallylamine Hydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₀N₂

[ Molecular Weight ]:
334.49800

[ Exact Mass ]:
334.24100

[ PSA ]:
6.48000

[ LogP ]:
4.25450

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
45

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Clinical pharmacokinetics of ketobemidone. Its bioavailability after rectal administration.

Eur. J. Clin. Pharmacol. 19(3) , 217-23, (1981)

The pharmacokinetic constants and rectal bioavailability of the narcotic analgesic ketobemidone were determined in six male patients after surgery. Plasma concentrations were measured following intrav...

The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.

Pharmacol. Toxicol. 79(2) , 103-4, (1996)

Ketobemidone plus (RS)-3-dimethylamino-1,1-diphenylbut-1-ene (A29) is more potent at NMDA receptors than ketobemidone alone: evidence for A29 as a non-competitive NMDA receptor antagonist.

Pharmacol. Toxicol. 82(3) , 157-60, (1998)

The opioid, ketobemidone, has previously been shown to be a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. In Denmark, ketobemidone is available in a formulation which contains ketob...