Protoporphyrin IX

Names

[ CAS No. ]:
553-12-8

[ Name ]:
Protoporphyrin IX

[Synonym ]:
3,3'-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl)dipropanoic acid
3,3'-(7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-diyl)dipropanoic acid
Kammerer's prophyrin
1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic Acid
MFCD00151109
3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphyrin-2,18-diyl)dipropanoic acid
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-
protoporphyrin
EINECS 209-033-7
Kammerer's porphyrin
protoporphyrin-IX
7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid
Protoporphyrin IX

Biological Activity

[Description]:

Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Yasushi Nakai, et al.Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1122.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₄N₄O₄

[ Molecular Weight ]:
562.658

[ Flash Point ]:
632.4±34.3 °C

[ Exact Mass ]:
562.257996

[ PSA ]:
130.90000

[ LogP ]:
7.33

[ Appearance of Characters ]:
Powder | purple

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.674

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.

Br. J. Cancer 111(5) , 874-82, (2014)

Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all-trans retinoic acid (ATRA)), which promotes differentiation of promyelocytic blasts. Although co-administration of ...

Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage.

Chem. Biol. Interact. 221 , 77-87, (2014)

The clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with adverse effects in the kidney. Indomethacin, an NSAID that has been shown to induce oxidative stress in the ...

Comparison of protoporphyrin IX produced cell proliferation inhibition between human breast cancer MCF-7 and MDA-MB-231 cells.

Pharmazie 69(8) , 621-8, (2014)

Protoporphyrin IX (PpIX) is an effective hematoporphyrin derivative, widely adopted in photodynamic therapy (PDT) and sonodynamic therapy (SDT). As a sensitizer, PpIX could significantly enhance laser...