Octamethylcyclotetrasiloxane
Names
[ CAS No. ]:
556-67-2
[ Name ]:
Octamethylcyclotetrasiloxane
[Synonym ]:
EINECS 209-136-7
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
Octamethylcyclotetrasiloxane
MFCD00003269
2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
175.0±0.0 °C at 760 mmHg
[ Melting Point ]:
17-18 °C(lit.)
[ Molecular Formula ]:
C8H24O4Si4
[ Molecular Weight ]:
296.616
[ Flash Point ]:
63.2±23.0 °C
[ Exact Mass ]:
296.075165
[ PSA ]:
36.92000
[ LogP ]:
2.87360
[ Vapour density ]:
1 (vs air)
[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.423
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GZ4397000
- CHEMICAL NAME :
- Cyclotetrasiloxane, octamethyl-
- CAS REGISTRY NUMBER :
- 556-67-2
- BEILSTEIN REFERENCE NO. :
- 1787074
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C8-H24-O4-Si4
- MOLECULAR WEIGHT :
- 296.68
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1540 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48 gm/m3/8H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1770 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Liver - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 794 uL/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - hematuria
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ppm/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530406
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 697 ppm/6H/28D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 697 ppm/6H/28D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3232 No. of Facilities: 128 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 3383 (estimated) No. of Female Employees: 1689 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H361-H413
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R53;R62
[ Safety Phrases ]:
S36/37-S46-S51-S61
[ RIDADR ]:
UN 1993 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
GZ4397000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Environ. Technol. 30(10) , 1073-83, (2009)
Siloxanes are widely used in different applications: health care, dry cleaning, household products, paints and coatings, paper, personal care, for example. This explains their prevalence in the enviro...
Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic codEnviron. Pollut. 190 , 109-14, (2014)
Spatial distribution and relationship of allometric measurements (length, weight and age) to liver concentrations of cyclic volatile methyl siloxanes (cVMS) including octamethylcyclotetrasiloxane (D4)...
[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].Zhong Yao Cai 31(5) , 677-8, (2008)
To analyze the volatile oils chemical constituents of roots of Actinidia deliciosa.The volatile oils fraction of roots of Actinidia deliciosa. were extracted by water vapor distilling, and then the co...