Teclozan

Names

[ Name ]:
Teclozan

[Synonym ]:
TECLOZAN
EINECS 226-934-0
Teclosan
1,4-Bis-<N-dichloracetyl-N-(2-ethoxy-ethyl)-aminomethyl>-benzol
Teclozanum [INN-Latin]
Falmonox
Teclosine
Teclozine

Biological Activity

[Description]:

Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Gonzales MLM, et al. Antiamoebic drugs for treating amoebic colitis. Cochrane Database Syst Rev. 2019;1(1):CD006085. Published 2019 Jan 9.

[2]. Díaz, V. M. M. . Pharmacological Treatment of Giardiasis. In: Rodriguez-Morales, A. J. , editor. Current Topics in Giardiasis [Internet]. London: IntechOpen; 2017.

Chemical & Physical Properties

[ Density]:
1.294g/cm3

[ Boiling Point ]:
585.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₈Cl₄N₂O₄

[ Molecular Weight ]:
502.25900

[ Flash Point ]:
308.1ºC

[ Exact Mass ]:
500.08000

[ PSA ]:
59.08000

[ LogP ]:
4.02420

[ Index of Refraction ]:
1.541

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC7720000

CHEMICAL NAME :: Acetamide, N,N'-(1,4-phenylenebis(methylene))bis(2,2-dichloro-N- (2-ethoxyethyl)-

CAS REGISTRY NUMBER :: 5560-78-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H28-Cl4-N2-O4

MOLECULAR WEIGHT :: 502.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952- Volume(issue)/page/year: 10,503,1961