Lignoceric acid

Names

[ CAS No. ]:
557-59-5

[ Name ]:
Lignoceric acid

[Synonym ]:
Lignoceric acid
Tetracosanoic acid
EINECS 209-180-7
MFCD00002810
n-tetracosanoic acid

Biological Activity

[Description]:

Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Heat flux induced by lignoceric acid in HepG2 peroxisomes was exothermic, indicating normal peroxisomal metabolism[1].

[References]

[1]. Anna Petroni, et al. Thermogenic flux induced by lignoceric acid in peroxisomes isolated from HepG2 cells and from X-adrenoleukodystrophy and control fibroblasts. J Cell Physiol. 2019 Aug;234(10):18344-18348.

[2]. J M Bourre, et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem. 1977 Jan 3;72(1):41-7.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
405.9±8.0 °C at 760 mmHg

[ Melting Point ]:
80-82 °C

[ Molecular Formula ]:
C₂₄H₄₈O₂

[ Molecular Weight ]:
368.637

[ Flash Point ]:
182.2±13.3 °C

[ Exact Mass ]:
368.365417

[ PSA ]:
37.30000

[ LogP ]:
11.40

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

Synthetic Route

Click to get detail synthetic route

Articles

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.

Clin. Chim. Acta 438 , 126-34, (2014)

As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This stud...