18-Hydroxycorticosterone

Names

[ CAS No. ]:
561-65-9

[ Name ]:
18-Hydroxycorticosterone

[Synonym ]:
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
18-Hydroxy Corticosterone
EINECS 209-221-9
11beta,18,21-Trihydroxypregn-4-ene-3,20-dione

Biological Activity

[Description]:

18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₀O₅

[ Molecular Weight ]:
362.46000

[ Flash Point ]:
2 °C - closed cup (lit.)

[ Exact Mass ]:
362.20900

[ PSA ]:
94.83000

[ LogP ]:
1.63910

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

J. Med. Chem. 53 , 1712-25, (2010)

Reducing aldosterone action is beneficial in various major diseases such as heart failure. Currently, this is achieved with mineralocorticoid receptor antagonists, however, aldosterone synthase (CYP11...

["High pouch output" syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy].

Chirurg. 72(12) , 1446-52, (2001)

The two-phase restorative proctocolectomy is the treatment of choice for surgical therapy of the familial adenomatous polyposis (FAP) and also for the ulcerative colitis (UC). Besides the well-known c...

Dose-dependence of the effects of corticosterone and the non-glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger.

Endocr. Res. 24(3-4) , 601-5, (1998)

Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX r...