8-Hydroxyguanine

Names

[ Name ]:
8-Hydroxyguanine

[Synonym ]:
8-OH-GUA
7,8-DIHYDRO-8-OXOGUANINE
2-AMINO-6,8-DIHYDROXYPURINE
8-Hydroxy-guanin
8-Oxo-7,8-dihydroguanine
8-OXOGUANINE
2-amino-7,9-dihydro-1H-purine-6,8-dione
2-AMINO-6,8-PURINEDIOL
8-Oxodihydroguanine
2-aminopurine-6,8-diol
8-OXOG
8-HYDROXYGUANINE
EINECS 227-035-6

Biological Activity

[Description]:

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10.

[2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50.

[3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.49g/cm3

[ Boiling Point ]:
327.7ºC at 760 mmHg

[ Melting Point ]:
>400ºC dec.

[ Molecular Formula ]:
C₅H₅N₅O₂

[ Molecular Weight ]:
167.12500

[ Flash Point ]:
152ºC

[ Exact Mass ]:
167.04400

[ PSA ]:
120.94000

[ Index of Refraction ]:
2.156

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%